Curriculum Vitae
Online Version: sensitive materials deleted
A. Personal Information
Thomas John Wiese, Social Security Number ***-**-****
Address: Department of Chemistry
Fort Hays State University
Hays, KS 67601
(785) 628-4505
FAX: (785) 628-4096
Internet address: twiese@fhsu.edu
Born 9 January 1964, LaCrosse, WI; U.S. Citizen
Married, 21 March 1992: no children
B. Education
B.S. Biochemistry 1986; University of Wisconsin-River Falls, River Falls,
WI.
Ph.D. Biochemistry 1990; University of North Dakota, Grand Forks, ND.
Dissertation title: Species- and Tissue-specific Distribution of Phosphoenolpyruvate
Carboxykinase. Minor field of study: Microbiology and Immunology.
C. Professional Experience
2001-present. Associate Professor of Chemistry, Fort Hays State University, Hays,
KS 67601.
August 1996-2001. Assistant Professor of Chemistry, Fort Hays State University,
Hays, KS 67601.
August 1992-August 1996. Post-doctoral Research Associate. Department of Internal
Medicine, University of Iowa, Iowa City, IA 52246.
August 1990-August 1992. Post-doctoral Research Associate. Department
of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
August 1989-August 1990. Graduate Research Assistant, Department of
Biochemistry and Molecular Biology, University of North Dakota, Grand Forks,
ND 58202.
August 1986-August 1989. Graduate Teaching Assistant, Department of
Biochemistry and Molecular Biology, University of North Dakota, Grand Forks,
ND 58202.
September 1983-May 1986. Teaching Assistant, Department of Chemistry,
University of Wisconsin-River Falls, River Falls, WI 54022.
D. Other Professional Activities
January 1987-May 1990. Biochemistry Tutor, biochemistry department undergraduate
courses and a graduate correspondence course.
May 1985-May 1986. Chemistry Tutor, freshman chemistry, UW-RF.
E. Professional Affiliations
1997-Present Sigma Xi
1986-Present American Association for the Advancement of Science
1983-Present American Chemical Society, Full Member
F. Research Interests
L-Fucose metabolism
Protein sorting and secretion
Diabetic complications
Glycoprotein structure and function
G. Current Projects
1. Biochemistry of L-Fucose-containing glycoproteins
2. Structure of lipochitooligosaccharides of Bradyrhizobium japonicuum.
H. Publications
Manuscripts Published or In Press
Tissue distribution of L-fucokinase in rodents. Erin N. Miller, Aaron L. Rupp,
Marian K. Lindberg and and Thomas J. Wiese. Comparative Biochemistry and Physiology,
Part B. 140: 513-520, 2005
Purification And Characterization of The L-fucose Transporter. Joshua R. Leck
and Thomas J. Wiese. Protein Expression and Purification 37: 288-293, 2004
Effect of L-Fucose and D-Glucose Concentration on L-Fucoprotein Metabolism
in Human Hep G2 Cells and Changes in Fucosyltransferase and -L-Fucosidase in
Liver of Diabetic Rats. Thomas J. Wiese, Joyce A. Dunlap and Mark A. Yorek.
Biochimica et Biophysica Acta. 1335: 61-72, 1997.
Regulation of the Na+/myo-Inositol Cotransporter mRNA
Levels in Streptozotocin-induced Diabetic Rats and by Hyperglycemia in
Cultured Cells. Thomas J. Wiese, William L. Lowe, Jr., and Mark A. Yorek.
Int. J. Diabetes. 4: 107-121, 1996.
Supplemental myo-inositol prevents L-Fucose-induced diabetic
neuropathy. A.A.F. Sima, J.A. Dunlap, E.P. Davidson, T.J. Wiese, R.L.F.
Lightle, D.A. Greene, M.A. Yorek. Diabetes 46: 301-306, 1997.
Localization and Regulation of Renal Na+/myo-Inositol
Cotransporter in Streptozotocin-induced Diabetic Rats. Thomas J. Wiese,
Kazumichi Matsushita, William L. Lowe, Jr., John B. Stokes, and Mark A.
Yorek. Kidney International 50: 1202-1211, 1996.
Synthesis of citrate from phosphoenolpyruvate and acetylcarnitine
by mitochondria from rabbit, pigeon, and rat liver: Implications for lipogenesis.
Thomas J. Wiese, Sherry A. Wuensch, and Paul D. Ray. Comparative Biochemistry
and Physiology 114B: 417-422, 1996.
Osmotic Regulation of Na+/myo-Inositol Cotransporter
mRNA Level and Activity in Endothelial and Neural Cells. Thomas J. Wiese,
Joyce A. Dunlap, Corinne E. Conner, John A. Grzybowski, William L. Lowe,
Jr., and Mark A. Yorek. Am.J.Phys. 270: C990-C997, 1996.
Reduced Na+/K+ ATPase Activity and Motor Nerve
Conduction Velocity in L-Fucose Fed Rats is Reversible After Dietary Normalization.
Mark A. Yorek, Thomas J. Wiese, Eric P. Davidson, Joyce A. Dunlap, and
Corinne E. Conner. Metabolism 45: 229-234, 1996.
L-Fucose is Accumulated via a Specific Transport System in Eukaryotic
Cells. Thomas J. Wiese, Joyce A. Dunlap and Mark A. Yorek. J. Biol.
Chem. 269: 22705-22711, 1994.
Reduced Motor Nerve Conduction Velocity and Na+/K+
ATPase Activity in Rats Maintained on a Diet Containing L-Fucose. Reversal
by myo-Inositol Supplementation. Mark A. Yorek, Thomas J. Wiese,
Eric P. Davidson, Joyce A. Dunlap, Mark R. Stefani, Corinne E. Conner,
Mikiko Kamijo, Douglas A. Greene, and Anders A.F. Sima. Diabetes
42: 1401-1406, 1993.
The Intracellular Distribution and Amounts of P-enolpyruvate
Carboxykinase Isozymes in Various Tissues of Several Mammals and Birds.
Thomas J. Wiese, David O. Lambeth, and Paul D. Ray. Comparative Biochemistry
and Physiology 100B: 297-302, 1991.
Abstracts
Fucokinase Distribution Varies Wiedely Within the Animal Kingdom. Bradley
J. Honas and Thomas J. Wiese. Chemical and Engineering News xx: xx, xxxx. Presented
at the xx Midwest Regional Meeting of the American Chemical Society; 26-28 October
2005.
L-Fucose Metabolism in Diabetic Rats and Hep G2 Cells Exposed to Hyperglycemia.
FASEB Journal 10, Supplement 1: A1426, 1996. Presented at the 1996 meeting of
the Federation of American Societies for Experimental Biology; 6-10 June 1996.
Localization and Regulation of Renal Na+/myo-Inositol
Cotransporter in Diabetic Rats. Mark Yorek, Thomas Wiese, William Lowe,
and John Stokes. Diabetes 45, Supplement 1: A, 1996.
Divergent Regulation of myo-Inositol Transport by Cultured Murine
Cerebral Microvessel Endothelial and Neuroblastoma Cells. Thomas J. Wiese,
Corinne E. Conner and Mark A. Yorek. Diabetes 44, Supplement 1: 232A, 1995.
Osmotic Regulation of myo-Inositol Transport by Cultured Murine
Cerebral Microvessel Endothelial and Neuroblastoma Cells. Thomas Wiese,
Corinne E. Conner and Mark A. Yorek. Diabetes43, Supplement 1: 126A, 1994.
Presented at the 1994 meeting of the American Diabetes Association; 10-12
June 1994.
Characterization of a Specific Transport System for L-Fucose in Eukaryotic
Cells. Thomas J. Wiese, Joyce A. Dunlap, and Mark Yorek. Symposium on Complications
of Diabetes Mellitus, October 6-9, 1993.
Reduced Motor Nerve Conduction Velocity and Na+/K+
ATPase Activity in Rats Fed a Diet Containing 10 or 20% L-Fucose. Reversal
by myo-Inositol Supplementation. Thomas Wiese, Mikiko Kamijo, and
Mark Yorek. Diabetes 42, Supplement 1: 193A, 1993.
Species- and Tissue-specific Distribution of Mitochondrial and Cytosolic
Isozymes of Phosphoenolpyruvate Carboxykinase. T. J. Wiese, D. O.
Lambeth and P. D. Ray. Chemical and Engineering News 67: 64, 1989. Presented
at the 22nd Great Lakes Regional Meeting of the American Chemical Society;
31 May-2 June 1989.
Species- and Tissue-specific Distribution of Mitochondrial and Cytosolic
Isozymes of Phosphoenolpyruvate Carboxykinase. Thomas J. Wiese,
David O. Lambeth and Paul D. Ray. Proceedings of the North Dakota Academy
of Science 43: 89, 1989. Presented at the 1989 meeting of the North Dakota
Academy of Science, 27 and 28 April 1989
Books and/or Chapters
Reviews
Manuscripts In Preparation or Submitted
I. Invited Talks
Sigma Xi 2x
"L-Fucose-fed Rat Model of Diabetic Neuropathy." Fort Hays State University,
Hays, KS 67601. 21 May 1996.
"Elucidation of the Carbohydrate Structure of Recombinant Human Chorionic
Gonadotropin." University of Iowa, Iowa City, IA 52241. 15 March 1992.
"Regulation of Phosphoenolpyruvate Carboxykinase by Insulin."
Washington University School of Medicine, St. Louis, MO 63110. 12 November
1991.
"Role of the Cytoplasmic and Mitochondrial Isozymes of Phosphoenolpyruvate
Carboxykinase" Washington University School of Medicine, St. Louis, MO
63110. 15 March 1990.
J. Honors and Awards
1990-1992. Recipient of Diabetes Training Grant, NIH
1992-1993. Recipient of Endocrine Training Grant, NIH.
K. Physical Facilities
Office: 120 sq.ft.
Laboratory: 1000 sq.ft.
L. Personnel Supervised
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M. Funding
Pending
Current
Previous
Elucidation of Fucosylation Index as a Function of Protein Overexpression. Spring
2005, $*,***.
Cellular Localization of Brain Fucose-metabolizing Enzymes. Summer 2005, $*,***
CAREER: Biochemistry of L-Fucose-containing Glycoproteins and Retention of
Under-represented Chemistry Majors. 6/99-7/03, $***,***
L-Fucose as a Possible Mediator of Diabetic Embryopathy. 1 November 1993 -
1 November 1995. $**,***.
N. References
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Last Modified September 5, 2005
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