The monobactam family contains a cyclic beta-lactam structure which is unique in that it is completely synthesized (man-made). Aztreonam is perhaps the most widely known representative of the monobactam family. This drug is active against many of the gram negative aerobic organisms and is essentially resistant to beta-lactamase/cephalosporinase degradation. Currently, no monobactams are available for the treatment of AOM in children.